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ISSN: 1557-4962 (Print)
ISSN: 1557-4970 (Online)
Research Article Open Access

β-Naphthalene Incorporated Thiazole-5-Carboxamides/Thiazole -5- Ketones: Design, Synthesis and Anticonvulsant Screening against Two Seizure Models

Mohammed Faiz Arshad1, Faisal Al-Otaibi1, Gulam Mustafa1, Saad Shousha2 and Abdulrahman Alshahrani1
  • 1 Shaqra University, Saudi Arabia
  • 2 Benha University, Egypt

Abstract

A bunch of β-naphthalene incorporated thiazole-5-carboxamides/thiazole -5- ketones (7a-7o& 8a-8e) were prepared by reacting 4-methyl-2-(naphthalen-2-yl)thiazole-5-carbonyl chloride with appropriate amines. Structures of all the compounds were explained by elemental analysis, FT-IR, 1H NMR and mass spectral data. The compounds were evaluated for their anticonvulsant activity employing MES and chemoshock (scPTZ) seizure tests. Neurotoxicity was also assessed. Majority of these compounds exhibited significant activity against both animal models; however, compounds 7e, 7j, 7n and 8c displayed promising activity and could be considered as leads for further investigations.

American Journal of Pharmacology and Toxicology
Volume 14 No. 1, 2019, 27-37

DOI: https://doi.org/10.3844/ajptsp.2019.27.37

Submitted On: 26 January 2019 Published On: 29 August 2019

How to Cite: Arshad, M. F., Al-Otaibi, F., Mustafa, G., Shousha, S. & Alshahrani, A. (2019). β-Naphthalene Incorporated Thiazole-5-Carboxamides/Thiazole -5- Ketones: Design, Synthesis and Anticonvulsant Screening against Two Seizure Models. American Journal of Pharmacology and Toxicology, 14(1), 27-37. https://doi.org/10.3844/ajptsp.2019.27.37

Open AccessCopyright: © 2019 Mohammed Faiz Arshad, Faisal Al-Otaibi, Gulam Mustafa, Saad Shousha and Abdulrahman Alshahrani. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • Thiazole
  • MES
  • scPTZ
  • Anticonvulsant Activity