Modulatory Effects of Bryophyllum Pinnatum Leaves Extract on Peroxidation Indices of CCl₄ Induced-Hepatotoxicity in Wistar Albino Rats

Abstract

This research investigated the modulatory effect of methanol extract of Bryophyllum pinnatum leaves on peroxidation indices of CCl₄-induced hepatotoxicity. Thirty rats of average weight 150g divided into six groups of 5 rats each were used for the study. Group one (control) received water and paraffin for ten days. Group two (treatment control) received water only, group 3 (standard control), received a 100 mg/kg b.w of ascorbic acid, groups 4, 5 and 6 received 200, 400 and 600 mg/kg b.w of Bryophyllum pinnatum extract, respectively. Hepatotoxicity was induced by CCl₄ administration in groups 2 to 6 on the 7^th and 8^th days. There was significant increase in the level of high density lipoprotein (HDL) and non-significant decreases in total cholesterol and triacylglycerol in the extract treated groups (4-6) compared to group two (CCl₄ untreated). There was a significant increase in the level of low density lipoprotein (LDL) in the extract treated groups (4-6) compared to group one. Animals in groups 4-6 showed a significant decrease in MDA concentration compared to that of group one. Report from this study shows that Bryophyllum pinnatum extract has modulatory effect on the lipid profile of Wistar rats intoxicated with CCL₄.