Research Article Open Access

ANTIOPHIDIAN ACTIVITY OF BROSIMUM GUIANENSE (AUBL) HUBER

Jose Adolfo Homobono Machado Bittencourt1, Nayana Keyla Seabra de Oliveira1, Maxwell Santos Cabral1, Jose Renato Ribeiro2, Shayanne Vanessa Correia Henriques1, Leide Caroline dos Santos Picanço1, Cleydson Breno dos Santos1, Didier Stien3, Jose Carlos Tavares Carvalho1 and Jocivania Oliveira da Silva1
  • 1 Federal University of Amapá, Brazil
  • 2 , Brazil
  • 3 , France

Abstract

Snakebites envenomations are a problem public health in worldwide due to the high rates of morbidity and mortality. The Bothrops venom causes local tissue damage and inflammation is one of the most important events that occur. At present, effective treatment for snakebites is serum therapy with antivenom, which neutralizes systemic alterations but does not prevent local damage that can cause disabilities. Many plants are used in popular medicine to treat these accidents but few attempts have been made to investigate the scientific validity of these assertions. In Amazon region, indigenous and local people use the macerated bark of Brosimum guinanensis applied in the form of cataplasm, on the site of snakebite. This study aimed to analyze the ability of the Brosimum guianensis aqueous extract in the neutralization several effects induced by Bothrops atrox snake venom to investigate the scientific validity of folk medicine informations by means of controlled experiments. Our results showed that Brosimum guianensis aqueous extract was not effective to inhibit oedema, peritonitis, coagulant, myotoxic, phospholipase A2 activity (indirect hemolytic method) induced by B. atrox venom, but was able to inhibited significantly hemorrhagic and nociceptive activities. These results support a potential effect of this extract as a compounds source for biotechonological application and synthesis of new drugs with therapeutic purpose.

American Journal of Pharmacology and Toxicology
Volume 9 No. 2, 2014, 148-156

DOI: https://doi.org/10.3844/ajptsp.2014.148.156

Submitted On: 26 January 2014 Published On: 13 May 2014

How to Cite: Bittencourt, J. A. H. M., de Oliveira, N. K. S., Cabral, M. S., Ribeiro, J. R., Henriques, S. V. C., Picanço, L. C. D. S., Santos, C. B. D., Stien, D., Carvalho, J. C. T. & da Silva, J. O. (2014). ANTIOPHIDIAN ACTIVITY OF BROSIMUM GUIANENSE (AUBL) HUBER. American Journal of Pharmacology and Toxicology, 9(2), 148-156. https://doi.org/10.3844/ajptsp.2014.148.156

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Keywords

  • Bothrops Atrox
  • Snake Venom
  • Brosimum Guianense
  • Medicinal Plant