Research Article Open Access

Reversal of Dexamethasone Depressant Action in Wound Healing by Ficus Benghalensis L. Roots

Krishna Murti1 and Upendra Kumar2
  • 1 Singhania University, India
  • 2 College of Pharmacy, India

Abstract

Problem statement: Ficus benghalensis is widely used plant world wide traditionally as well as scientifically. It has a wide uses in various medical ailments. As a part of pharmacological evaluations, we have carried out wound healing activity specially in dexamethasone depressed healing conditions. Approach: Wound healing activity was established by two medels namely incision and excision. Results: The roots of Ficus benghalensis clearly reverted the antihealing in presence of dexamethasone treated animals. It happened through increase in breaking strength in incision model and increase in percentage wound contraction and reduction in period of epithelialization. Conclusion: Presence of various chemical constituents in the roots of Ficus benghalensis specially saponins, flavanoids, taannins and alkaloids were responsible for antagonizing the antihealing effect of dexamethasone treated animals.

American Journal of Pharmacology and Toxicology
Volume 6 No. 2, 2011, 68-75

DOI: https://doi.org/10.3844/ajptsp.2011.68.75

Submitted On: 3 June 2011 Published On: 17 September 2011

How to Cite: Murti, K. & Kumar, U. (2011). Reversal of Dexamethasone Depressant Action in Wound Healing by Ficus Benghalensis L. Roots. American Journal of Pharmacology and Toxicology, 6(2), 68-75. https://doi.org/10.3844/ajptsp.2011.68.75

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Keywords

  • Ficus benghalensis
  • wound healing
  • dexamethasone treated
  • incision wound
  • excision wounds
  • wound models
  • drug administration
  • Analysis Of Variance (ANOVA)
  • wistar rats