Research Article Open Access

Antitussive Activity Directed Isolation of Compounds from Onosma hispidum

Shahina Naz1, Rafeeq A. Khan1, Rahmanullah Siddiqi1 and Syed A. Sayeed1
  • 1 University of Karachi, Pakistan

Abstract

The chemical investigation of the ethanolic extract of the root bark of Onosma hispidum following antitussive activity directed isolation led to the isolation of 4-hydroxy-3-methoxy cinnamic acid (mCA) and 4-hydroxy-3-methoxy benzoic acid (mBA) which have been reported for the first time in this species. Antitussive activity of the compounds was evaluated by reduction in frequency of cough induced by SO2 gas in mice. In addition to these compounds, the crude ethanolic extract and methanolic fraction showed highly significant antitussive activity (p< 0.001, Students t test) compared to control. A dose-dependent inhibition of cough was observed with the extracts and the pure compounds and the results were also comparable with the effect produced by dextromethorphan- a standard antitussive drug.

American Journal of Pharmacology and Toxicology
Volume 1 No. 1, 2006, 1-4

DOI: https://doi.org/10.3844/ajptsp.2006.1.4

Submitted On: 13 May 2006 Published On: 31 March 2006

How to Cite: Naz, S., Khan, R. A., Siddiqi, R. & Sayeed, S. A. (2006). Antitussive Activity Directed Isolation of Compounds from Onosma hispidum. American Journal of Pharmacology and Toxicology, 1(1), 1-4. https://doi.org/10.3844/ajptsp.2006.1.4

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Keywords

  • Onosma hispidum
  • root bark
  • antitussive activity
  • 4-hydroxy-3-methoxy cinnamic acid and 4-hydroxy-3-methoxy benzoic acid