Double Application of Translocator Protein Ligands and RAW Cells Inflammatory Milieu

Abstract

Ligands targeting the translocator protein exhibit a variety of anti-inflammatory and neuroprotective properties. A double application of eight translocator protein ligands to activated murine macrophage-like cells changed to a different extent the levels of secreted reactive nitrogen intermediates, pro- and anti-inflammatory cytokines. To our knowledge this is the first report suggesting that multiple applications of different translocator protein ligands may have selective effects on the macrophage inflammatory milieu that do not appear to be related to just the ligand affinity.