Evaluation the Synergistic Effect of High Dose Radiation of Radioiodine on the Immune System Suppressed By Cyclosporine

Abstract

Cyclosporine is an immunosuppressant drug and iodine-131 is the diagnostic and therapeutic radioisotope in nuclear medicine. In this study, we aimed to evaluate the synergistic effect of high-dose radiation of radioiodine on the suppression of the immune system of BALB/cmice after receiving cyclosporine. A total of 50 mice BALB/c were randomly divided into two groups (control and test). Then, 50 mg kg^-1 body weight cyclosporine was given to both groups. After 24 h, 0.5 mL iodine-131 was given to the test group and in the control group the same volume of normal saline was given. Data analysis was done using SPSS V.20 and p value <0.05 was considered significant. After 30 days of monitoring, only 2 deaths (8%) occurred in the control group, however 16 deaths (64%) were observed in the test group. Statistical analysis of the data indicated that there is a significant relationship (p value <0.0005) between injecting radioiodine and the mortality rate in mice receiving cyclosporine and proves the synergistic effect of these two factors. Based on the results, iodine-131 can be introduced as a stimulating and synergistic factor on the suppression of the immune system of BALB/cmice and subsequent death.