Alterations of HDL Subclasses in Different Lipid Levels of Men and Women

Abstract

With the increase of plasma TG level, both in men and women, apoA-I concentrations of preβ1-HDL and HDL3a were significantly higher while HDL2a and HDL2b were significantly lower. Similarly, with the increase of plasma LDL-C level, apoA-Iconcentrations of preβ1-HDL, HDL3c(in men) and HDL3b were significantly higher while apoA-Iconcentrations of HDL2b were significantly lower. And with the decrease of plasma HDL-C, apoA-Iconcentrations of preβ1-HDL, HDL3Cand HDL3b were significantly higher while apoA-Iconcentrations of HDL2a and HDL2b were significantly lower. In addition, apoA-Iconcentrations of preβ1-HDL was significantly lower in women TG <1.7 mmol/L and TG 1.7～2.5 mmol/L vs. men groups. And apoA-Iconcentrations of HDL2b in women LDL-C <2.6 mmol/L, LDL 2.6～3.3 mmol/L and HDL-C 1.0～1.6 mmol/L, HDL-C <1.0 mmol/L groups were significantly higher than men groups. In all subjects, with the increase of TG, LDL-C and decrease of HDL-C, the particle size of HDL shifted towards smaller sizes, which, in turn, indicates that the maturation of HDL may be impeded in those subjects with abnormal lipids profile. In women HDL particles are bigger than the men, which potentially result in the gender differences in CHD risk factors and susceptibility to atherosclerosis.