Effect of Therapeutic and Double Therapeutic Doses of Ivermectin on Oxidative Status and Reproductive Hormones in Male Rabbits

Abstract

To investigate the biochemical alterations of oxidative status and male sexual hormones, thyroid hormones, cortisol, liver function and kidney function; sixty male New Zealand White rabbits were equally allotted according to their body weight into two groups. Control samples were collected before subcutaneous injection of rabbits by ivermectinin Therapeutic (TD) and Double Therapeutic Doses (DTD). After injection blood samples were collected from ear vein at 1^st, 3^rd and 7^th day of experiment and subjected to the biochemical analysis of urea, uric acid, creatinine, aspartate transaminase, alanine transaminase, lactate dehydrogenase, creatine phosphokinase, triiodothyronine, thyroxin, nitric oxide, total antioxidant capacity, cortisol, testosterone and free testosterone. The obtained data of both TD and DTD revealed a significant increase in urea, uric acid, creatinine, aspartate transaminase, alanine transaminase, lactate dehydrogenase, creatine phosphokinase, triiodothyronine, thyroxin, nitric oxide, cortisol, testosterone and free testosterone while total antioxidant capacity levels were significantly decreased. From the date data of the current study on TD and DTD with a higher value in the DTD. We can conclude that ivermectin induced deleterious effects on kidneys and hepatic functions, oxidative stress, weight loss and increased testosterone and free testosterone.